Medullary Raphe and Thermoregulation

Grant number: 232305 | Funding period: 2003 - 2005

Completed

Abstract

Our lives depend upon maintaining the correct body temperature. Failure to regulate it properly may be lethal. This is particularly true in the elderly, who are more susceptible on the one hand to heat stroke and on the other to hypothermia. Many die each year from both these causes. Body temperature is regulated by the brain, yet our understanding of how and where in the brain this happens is poor. This proposal aims to work out the 'wiring diagram' of brain temperature control pathways in rats and to begin to extend this knowledge to humans. This work will generate new knowledge about a vital function. The insights obtained will inform and guide future strategies in aged care, intensive ca..

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Related publications (6)

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The 'inflammatory reflex' acts through efferent neural connections from the central nervous system to lymphoid organs, particularl..

Processing of central and reflex vagal drives by rat cardiac ganglion neurones: An intracellular analysis

RM Mcallen, LM Salo, JFR Paton, AE Pickering

2011-12-01

Cardiac vagal tone is an important indicator of cardiovascular health, and its loss is an independent risk factor for arrhythmias ..

Preoptic-raphé connections for thermoregulatory vasomotor control

M Tanaka, MJ McKinley, RM McAllen

2011-03-30

Blood flow to glabrous skin such as the rat's tail determines heat dissipation from the body and is regulated by sympathetic vasoc..

The peptide or the neuron?

R Mcallen

2010-11-01

Multiple thermoregulatory effectors with independent central controls

RM McAllen, M Tanaka, Y Ootsuka, MJ McKinley

2010-05-01

This review first considers how mammalian body temperature regulation evolved, and how the brain's responses to thermoregulatory c..

Roles of two preoptic cell groups in tonic and febrile control of rat tail sympathetic fibers

M Tanaka, MJ McKinley, RM McAllen

2009-04-01

In response to cold and in fever, heat dissipation from the skin is reduced by sympathetic vasoconstriction. The preoptic region h..

University of Melbourne Researchers

Robin McAllen